AP2A1

mutation — cross-omics
Cross-omicsMUTATION → RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, AP2A1 mutation is significantly associated with the RNA expression of many other genes, with 523 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AP2A1-associated genes across cancer lineages are HKDC1, MRGPRG, and MMP27. Each is linked with AP2A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP2A1-to-partner and partner-to-AP2A1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP2A1→partner) and Y-score (partner→AP2A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BLOOD_LeukemiaHKDC1 →+1.140+3.379<.001.00632
LUNG_NSCLC_LUADMRGPRG →+0.034+4.544<.001.00332
BLOOD_LymphomaMMP27 →+0.026+5.209<.001.00532
LARGE_INTESTINEZNF410 →+0.422+2.502.001.00532
LARGE_INTESTINEDESI2 →+0.433+2.502.006.00532
LARGE_INTESTINENEDD1 →+0.646+2.502<.001.00532
Each partner links to its Q-omics profile. Showing the 6 strongest of 523 associations by consensus.

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