AP1S3

Across TCGA pan-cancer cohorts, AP1S3 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated AP1S3 data layer compared with 27 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher AP1S3 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated AP1S3 expression acts as an unfavorable survival marker, although some lineages such as COAD show a favorable association.

COAD are the cancer types where AP1S3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.468	.035	4	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

AP1S3–COAD (DFS)

Open the COAD breakdown →