AP1S3

Across TCGA patient cohorts, AP1S3 RNA expression is significantly associated with the mutation status of many other genes, with 10,404 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP1S3-associated genes across cancer lineages are SYNE1, DNAH10, and TENM3. Each is linked with AP1S3 in more than 5 cancer types. Because this analysis shows association rather than direction, both AP1S3-to-partner and partner-to-AP1S3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYNE1 grouped by AP1S3-low versus AP1S3-high in UCEC.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP1S3→partner) and Y-score (partner→AP1S3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SYNE1 →	+1.527	+0.351	<.001	<.001	3	6
UCEC	DNAH10 →	+1.884	+0.433	<.001	<.001	3	5
COAD	TENM3 →	+2.083	+0.455	<.001	<.001	3	5
UCEC	ERBB4 →	+2.632	+0.502	<.001	<.001	3	5
STAD	MUC16 →	+1.807	+0.434	<.001	<.001	3	5
HNSC	LAMA2 →	+2.941	+0.486	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,404 associations by consensus.

SYNE1 by AP1S3 expression — UCEC

Explore this box plot interactively →