AP1S3

Across TCGA cell cohorts, AP1S3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,871 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible AP1S3-associated GO terms across cancer lineages are Regulation of heart rate by cardiac conduction, Death-inducing signaling complex assembly, and Regulation of hepatocyte apoptotic process. Each is linked with AP1S3 in more than 8 cancer types. Because this analysis shows association rather than direction, both AP1S3-to-partner and partner-to-AP1S3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of heart rate by cardiac conduction grouped by AP1S3-low versus AP1S3-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AP1S3→partner) and Y-score (partner→AP1S3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of heart rate by cardiac conduction →	+0.205	+1.127	<.001	.001	3	9
LARGE_INTESTINE	Death-inducing signaling complex assembly →	+0.140	+1.627	<.001	<.001	3	9
SOFT_TISSUE	Regulation of hepatocyte apoptotic process →	+0.115	+1.630	.007	.008	3	8
SOFT_TISSUE	Negative regulation of hepatocyte apoptotic process →	+0.115	+1.630	.007	.008	3	8
PANCREAS	Negative regulation of actin filament polymerization →	+0.240	+1.719	<.001	<.001	3	8
SOFT_TISSUE	Regulation of cell projection size →	+0.329	+2.643	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,871 associations by consensus.

Regulation of heart rate by cardiac conduction by AP1S3 expression — STOMACH

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