AP1S2

Across TCGA patient cohorts, AP1S2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP1S2-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and FoxM1. Each is linked with AP1S2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP1S2-to-partner and partner-to-AP1S2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by AP1S2-low versus AP1S2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP1S2→partner) and Y-score (partner→AP1S2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.107	-3.295	.014	.009	3	1
UCEC	A-Raf_pS299 →	-0.169	-3.459	.001	.005	3	1
UCEC	FoxM1 →	+0.249	+3.009	.027	.019	3	1
UCEC	ACC1 →	+0.401	+3.013	.011	.018	3	1
UCEC	JNK2 →	+0.221	+2.331	.011	.019	3	1
UCEC	Ku80 →	+0.379	+3.920	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

14-3-3_beta by AP1S2 expression — UCEC

Explore this box plot interactively →