AP1S2

Across TCGA cell cohorts, AP1S2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,635 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible AP1S2-associated GO terms across cancer lineages are Regulation of mitotic metaphase/anaphase transition, Regulation of metaphase/anaphase transition of cell cycle, and Regulation of chromosome segregation. Each is linked with AP1S2 in more than 12 cancer types. Because this analysis shows association rather than direction, both AP1S2-to-partner and partner-to-AP1S2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitotic metaphase/anaphase transition grouped by AP1S2-low versus AP1S2-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AP1S2→partner) and Y-score (partner→AP1S2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of mitotic metaphase/anaphase transition →	+0.125	+1.197	<.001	.003	3	13
KIDNEY	Regulation of metaphase/anaphase transition of cell cycle →	+0.115	+1.197	<.001	.003	3	12
KIDNEY	Regulation of chromosome segregation →	+0.105	+1.433	<.001	<.001	3	11
PANCREAS	Platelet dense granule organization →	+0.091	+1.535	<.001	<.001	3	11
OVARY	Melanosome assembly →	+0.087	+1.410	<.001	.004	3	11
KIDNEY	Regulation of mitotic sister chromatid separation →	+0.157	+1.293	<.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,635 associations by consensus.

Regulation of mitotic metaphase/anaphase transition by AP1S2 expression — KIDNEY

Explore this box plot interactively →