AP1S1

Across TCGA pan-cancer cohorts, AP1S1 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated AP1S1 data layer compared with 28 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher AP1S1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated AP1S1 expression acts as an unfavorable survival marker.

KIRP are the cancer types where AP1S1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.277	0.867	.004	3	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

AP1S1–KIRP (DFS)

Open the KIRP breakdown →