AP1S1

Across TCGA pan-cancer cohorts, AP1S1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated AP1S1 data layer compared with 28 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher AP1S1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated AP1S1 expression acts as an unfavorable survival marker, although some lineages such as COAD and UCEC show a favorable association.

COAD, LSCC, and UCEC are the cancer types where AP1S1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	1.000	0.829	.016	60	view →
LSCC	DFS	Median	All	0.552	1.000	.001	33	view →
UCEC	OS	Median	All	0.972	0.845	.012	6	view →
LUAD	OS	Median	All	0.999	0.922	.015	5	view →
GBM	DFS	Median	All	0.443	0.298	.026	4	view →
CCRCC	OS	Median	II,III,IV	0.831	0.640	.037	2	view →
PDAC	DFS	Median	All	0.540	0.363	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

AP1S1–COAD (DFS)

Open the COAD breakdown →