AP1M2

Across TCGA patient cohorts, AP1M2 mutation is significantly associated with the RNA expression of many other genes, with 1,665 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP1M2-associated genes across cancer lineages are MTATP6P29, FXYD6P1, and SNED1. Each is linked with AP1M2 in more than 2 cancer types. Because this analysis shows association rather than direction, both AP1M2-to-partner and partner-to-AP1M2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTATP6P29 grouped by AP1M2-low versus AP1M2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP1M2→partner) and Y-score (partner→AP1M2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTATP6P29 →	+0.214	+2.470	<.001	.001	3	3
SKCM	FXYD6P1 →	+0.115	+2.894	<.001	.006	3	2
UCEC	SNED1 →	-0.503	-2.689	.007	.005	3	2
PRAD	RNU6-1060P →	+0.568	+7.939	<.001	.008	3	2
COAD	TDGF1P4 →	+0.137	+4.693	<.001	.007	3	2
COAD	MIR4504 →	+0.532	+4.602	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,665 associations by consensus.

MTATP6P29 by AP1M2 expression — UCEC

Explore this box plot interactively →