AP1M2

Across TCGA patient cohorts, AP1M2 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP1M2-associated genes across cancer lineages are Ku80, SETD2, and STAT5a. Each is linked with AP1M2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP1M2-to-partner and partner-to-AP1M2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by AP1M2-low versus AP1M2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP1M2→partner) and Y-score (partner→AP1M2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.207	+1.920	.029	.009	3	2
UCEC	SETD2 →	-0.173	-1.906	.048	.016	3	2
UCEC	STAT5a →	+0.382	+1.906	.017	.016	3	2
UCEC	Syk →	+0.423	+1.920	.005	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.821	+3.604	<.001	.001	3	2
UCEC	4E-BP1 →	+0.288	+1.904	.008	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Ku80 by AP1M2 expression — UCEC

Explore this box plot interactively →