AP1M2

Across TCGA cell cohorts, AP1M2 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AP1M2-associated genes across cancer lineages are PHOX2B, OR4S2, and SLC22A6. Each is linked with AP1M2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP1M2-to-partner and partner-to-AP1M2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHOX2B grouped by AP1M2-low versus AP1M2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP1M2→partner) and Y-score (partner→AP1M2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PHOX2B →	+0.021	+4.365	<.001	.002	3	2
SKIN	OR4S2 →	+0.043	+6.022	<.001	.001	3	1
SKIN	SLC22A6 →	+0.006	+6.022	<.001	.001	3	1
SKIN	MGAT4D →	+0.023	+4.977	<.001	.007	3	1
SKIN	PNMA6F →	+0.006	+4.977	<.001	.007	3	1
LARGE_INTESTINE	REG1B →	+2.047	+3.196	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

PHOX2B by AP1M2 expression — BLOOD_Leukemia

Explore this box plot interactively →