AP1M1

Across TCGA pan-cancer cohorts, AP1M1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated AP1M1 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher AP1M1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated AP1M1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

UCEC, PDAC, and COAD are the cancer types where AP1M1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.432	0.950	<.001	32	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	15	view →
COAD	DFS	Median	All	0.888	1.000	.023	12	view →
CCRCC	DFS	Quartile	II,III,IV	0.975	0.687	.016	11	view →
LUAD	OS	Tertile	II,III,IV	0.273	0.581	.023	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

AP1M1–UCEC (DFS)

Open the UCEC breakdown →