AP1M1

Across TCGA cell cohorts, AP1M1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AP1M1-associated genes across cancer lineages are TMSB4Y, ITGAD, and BPY2. Each is linked with AP1M1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP1M1-to-partner and partner-to-AP1M1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMSB4Y grouped by AP1M1-low versus AP1M1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP1M1→partner) and Y-score (partner→AP1M1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMSB4Y →	+1.377	+3.556	<.001	.007	3	1
LARGE_INTESTINE	ITGAD →	+0.009	+2.925	.003	.007	3	1
LARGE_INTESTINE	BPY2 →	+0.012	+3.700	<.001	.009	3	1
LARGE_INTESTINE	BPY2B →	+0.012	+3.700	<.001	.009	3	1
LARGE_INTESTINE	BPY2C →	+0.012	+3.700	<.001	.009	3	1
SKIN	OR56A1 →	+0.012	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

TMSB4Y by AP1M1 expression — LARGE_INTESTINE

Explore this box plot interactively →