AP1G1

Across TCGA patient cohorts, AP1G1 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP1G1-associated genes across cancer lineages are eIF4E, FOXO3a_pS318_S321, and INPP4B. Each is linked with AP1G1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP1G1-to-partner and partner-to-AP1G1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by AP1G1-low versus AP1G1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP1G1→partner) and Y-score (partner→AP1G1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.175	+3.013	.004	<.001	3	2
UCEC	FOXO3a_pS318_S321 →	-0.091	-1.513	.012	.006	3	2
UCEC	INPP4B →	-0.268	-2.321	.004	<.001	3	2
UCEC	mTOR_pS2448 →	-0.117	-2.074	.006	.004	3	2
UCEC	Notch1 →	+0.154	+1.939	<.001	.002	3	2
UCEC	p27_pT198 →	+0.089	+1.584	.004	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

eIF4E by AP1G1 expression — UCEC

Explore this box plot interactively →