AP1G1

Across TCGA cell cohorts, AP1G1 mutation is significantly associated with the RNA expression of many other genes, with 104 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AP1G1-associated genes across cancer lineages are NCF4, CILK1, and DNAH1. Each is linked with AP1G1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP1G1-to-partner and partner-to-AP1G1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCF4 grouped by AP1G1-low versus AP1G1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP1G1→partner) and Y-score (partner→AP1G1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NCF4 →	+0.970	+3.234	<.001	.004	3	1
LARGE_INTESTINE	CILK1 →	+0.691	+3.451	.007	.002	3	1
LARGE_INTESTINE	DNAH1 →	+1.086	+3.169	<.001	.009	3	1
LARGE_INTESTINE	ZNF831 →	+0.008	+2.425	<.001	.004	3	1
LARGE_INTESTINE	TMEM74B →	+0.978	+3.364	.008	.002	3	1
LARGE_INTESTINE	TLE3 →	+0.809	+3.364	.007	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 104 associations by consensus.

NCF4 by AP1G1 expression — LARGE_INTESTINE

Explore this box plot interactively →