AP1B1

Across TCGA patient cohorts, AP1B1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP1B1-associated genes across cancer lineages are STAT3_pY705, eEF2K, and Fibronectin. Each is linked with AP1B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP1B1-to-partner and partner-to-AP1B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by AP1B1-low versus AP1B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP1B1→partner) and Y-score (partner→AP1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.434	-2.058	<.001	<.001	3	2
BLCA	eEF2K →	+0.368	+2.999	.030	.035	3	2
UCEC	Fibronectin →	-0.232	-1.755	.028	.013	3	2
UCEC	GAPDH →	+0.343	+1.678	.045	.021	3	2
UCEC	MEK1 →	+0.442	+2.378	<.001	<.001	3	2
UCEC	Notch1 →	+0.119	+1.512	.008	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

STAT3_pY705 by AP1B1 expression — UCEC

Explore this box plot interactively →