AP1B1

Across TCGA cell cohorts, AP1B1 mutation is significantly associated with the RNA expression of many other genes, with 507 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AP1B1-associated genes across cancer lineages are KRT71, C9orf92, and CLRN2. Each is linked with AP1B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP1B1-to-partner and partner-to-AP1B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT71 grouped by AP1B1-low versus AP1B1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP1B1→partner) and Y-score (partner→AP1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	KRT71 →	+0.039	+3.643	<.001	.003	3	2
SOFT_TISSUE	C9orf92 →	+0.144	+4.369	<.001	.008	3	1
SOFT_TISSUE	CLRN2 →	+0.019	+4.369	<.001	.008	3	1
SOFT_TISSUE	GYPB →	+0.175	+4.635	<.001	.003	3	1
OESOPHAGUS	CYSLTR2 →	+0.040	+3.115	.004	.005	3	1
BLOOD_Leukemia	NOVA2 →	+0.247	+4.253	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 507 associations by consensus.

KRT71 by AP1B1 expression — OESOPHAGUS

Explore this box plot interactively →