AOPEP

Across TCGA cell cohorts, AOPEP mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible AOPEP-associated genes across cancer lineages are ZSWIM2, C1QA, and OR1L3. Each is linked with AOPEP in more than 1 cancer types. Because this analysis shows association rather than direction, both AOPEP-to-partner and partner-to-AOPEP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZSWIM2 grouped by AOPEP-low versus AOPEP-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AOPEP→partner) and Y-score (partner→AOPEP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ZSWIM2 →	+0.006	+4.807	<.001	.006	3	1
BLOOD_Myeloma	C1QA →	+0.206	+4.807	<.001	.006	3	1
SKIN	OR1L3 →	+0.014	+4.415	.001	.007	3	1
SKIN	CASP12 →	+0.042	+4.095	.001	.009	3	1
CNS	STRA8 →	+0.024	+4.754	<.001	.005	3	1
CNS	GNG8 →	+1.547	+4.643	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ZSWIM2 by AOPEP expression — BLOOD_Myeloma

Explore this box plot interactively →