AOC3

Across TCGA pan-cancer cohorts, AOC3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated AOC3 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher AOC3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated AOC3 expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

LUAD, HNSC, and GBM are the cancer types where AOC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.519	0.995	.031	11	view →
HNSC	DFS	Tertile	II,III,IV	0.886	0.973	.021	7	view →
GBM	OS	Tertile	All	0.731	0.364	.015	5	view →
CCRCC	OS	Median	All	0.890	0.787	.037	3	view →
LSCC	OS	Median	II,III,IV	0.928	0.781	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

AOC3–LUAD (DFS)

Open the LUAD breakdown →