AOC1

Across TCGA pan-cancer cohorts, AOC1 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of AOC1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where AOC1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types AOC1 is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

COAD, CCRCC, and PDAC are the cancer types where AOC1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AOC1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	IV	−1.350	<.001	11	view →
CCRCC	Male	All	−0.940	<.001	10	view →
PDAC	Female	All	+0.915	<.001	8	view →
LUAD	All	All	+0.308	.003	4	view →
HNSC	Male	III,IV	−0.588	.004	3	view →
OV	All	All	−0.920	.003	2	view →
LSCC	Male	All	−0.285	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

AOC1–COAD

Open the COAD breakdown →