AOAH

Across TCGA pan-cancer cohorts, AOAH mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of AOAH’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where AOAH mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types AOAH is over-expressed in tumor, although a few such as PDAC and LUAD show the opposite, repressed pattern.

CCRCC, HNSC, and PDAC are the cancer types where AOAH tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AOAH mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	II,III,IV	+0.931	<.001	11	view →
HNSC	All	All	+0.441	<.001	11	view →
PDAC	Male	II,III,IV	−0.618	<.001	5	view →
LUAD	All	II,III,IV	−0.218	.006	4	view →
LSCC	All	All	+0.177	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

AOAH–CCRCC

Open the CCRCC breakdown →