AOAH

Across TCGA patient cohorts, AOAH mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AOAH-associated genes across cancer lineages are Cyclin-E2, 4E-BP1_pT37_T46, and Caspase-8. Each is linked with AOAH in more than 2 cancer types. Because this analysis shows association rather than direction, both AOAH-to-partner and partner-to-AOAH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by AOAH-low versus AOAH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AOAH→partner) and Y-score (partner→AOAH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.159	+3.179	.031	.010	3	3
UCEC	4E-BP1_pT37_T46 →	-0.494	-3.308	.002	.009	3	2
UCEC	Caspase-8 →	-0.302	-3.558	.006	.002	3	2
UCEC	c-Met_pY1235 →	+0.079	+1.884	.015	.030	3	2
UCEC	Cyclin-B1 →	+0.790	+2.807	.001	.003	3	2
SKCM	Bim →	-0.212	-2.000	.027	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Cyclin-E2 by AOAH expression — UCEC

Explore this box plot interactively →