AOAH

Across TCGA cell cohorts, AOAH mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible AOAH-associated genes across cancer lineages are CCKAR, C1orf146, and NUDT10. Each is linked with AOAH in more than 1 cancer types. Because this analysis shows association rather than direction, both AOAH-to-partner and partner-to-AOAH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCKAR grouped by AOAH-low versus AOAH-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AOAH→partner) and Y-score (partner→AOAH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CCKAR →	+0.038	+4.409	<.001	.005	3	2
LUNG_NSCLC_LUAD	C1orf146 →	+0.020	+4.734	<.001	.002	3	1
LARGE_INTESTINE	NUDT10 →	+0.419	+3.807	<.001	.003	3	1
LARGE_INTESTINE	GRID2 →	+0.030	+3.777	<.001	.001	3	1
LARGE_INTESTINE	INSL5 →	+0.302	+3.626	<.001	.006	3	1
LARGE_INTESTINE	FAM71C →	+0.018	+3.632	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

CCKAR by AOAH expression — BLOOD_Leukemia

Explore this box plot interactively →