ANXA8L1

Across TCGA pan-cancer cohorts, ANXA8L1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ANXA8L1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ANXA8L1 RNA is repressed in tumor relative to normal tissue. In most cancer types ANXA8L1 is over-expressed in tumor, although a few such as LUAD and BRCA show the opposite, repressed pattern.

LUAD, BRCA, and COAD are the cancer types where ANXA8L1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANXA8L1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	−1.972	<.001	9	view →
BRCA	All	III,IV	−1.085	<.001	6	view →
COAD	All	II,III,IV	−0.295	<.001	6	view →
BLCA	Male	IV	+2.732	.020	4	view →
KICH	All	II,III,IV	−0.017	.001	4	view →
LIHC	Male	III,IV	−0.146	<.001	3	view →
KIRP	All	III,IV	+0.058	.019	3	view →
PAAD	All	All	+1.717	.022	2	view →
CHOL	All	All	+1.182	.020	2	view →
READ	All	All	−0.542	.001	2	view →
UCEC	All	All	−0.196	.007	2	view →
LUSC	Female	III,IV	+1.190	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ANXA8L1–LUAD

Open the LUAD breakdown →