ANXA3

Across TCGA patient cohorts, ANXA3 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANXA3-associated genes across cancer lineages are EGFR_pY1068, IGFBP2, and JNK_pT183_Y185. Each is linked with ANXA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANXA3-to-partner and partner-to-ANXA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ANXA3-low versus ANXA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANXA3→partner) and Y-score (partner→ANXA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.255	-2.584	.029	.011	3	1
UCEC	IGFBP2 →	-0.832	-3.000	.005	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.174	-3.169	.026	.019	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.433	-3.000	.039	.036	3	1
UCEC	PI3K-p85 →	+0.255	+3.009	.008	.019	3	1
UCEC	Rab25 →	-0.389	-2.999	.011	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

EGFR_pY1068 by ANXA3 expression — UCEC

Explore this box plot interactively →