Across TCGA pan-cancer cohorts, ANXA13 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of ANXA13’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where ANXA13 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ANXA13 is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.
COAD, CCRCC, and LUAD are the cancer types where ANXA13 tumor–normal differential expression is most reproducible.