ANXA1

Across TCGA patient cohorts, ANXA1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANXA1-associated genes across cancer lineages are PCNA, eIF4G, and FOXO3a_pS318_S321. Each is linked with ANXA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANXA1-to-partner and partner-to-ANXA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ANXA1-low versus ANXA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANXA1→partner) and Y-score (partner→ANXA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.390	+4.087	<.001	<.001	3	2
UCEC	eIF4G →	+0.370	+3.700	.003	.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.144	-2.105	.005	.017	3	1
UCEC	JNK_pT183_Y185 →	-0.241	-2.700	<.001	.005	3	1
UCEC	MEK1 →	+0.454	+2.321	.002	.006	3	1
UCEC	MIG-6 →	+0.082	+1.820	.045	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

PCNA by ANXA1 expression — UCEC

Explore this box plot interactively →