ANTXRL

Across TCGA patient cohorts, ANTXRL mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANTXRL-associated genes across cancer lineages are FOXO3a_pS318_S321, ACC1, and Notch1. Each is linked with ANTXRL in more than 1 cancer types. Because this analysis shows association rather than direction, both ANTXRL-to-partner and partner-to-ANTXRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by ANTXRL-low versus ANTXRL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANTXRL→partner) and Y-score (partner→ANTXRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.160	-2.990	.026	.036	3	1
UCEC	ACC1 →	+0.536	+3.000	.010	.037	3	1
UCEC	Notch1 →	+0.192	+2.817	.018	.036	3	1
UCEC	EGFR →	-0.260	-3.000	.004	.037	1	1
UCEC	eIF4G →	+0.363	+3.000	.043	.037	1	1
UCEC	HER3_pY1289 →	+0.101	+3.026	.042	.019	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

FOXO3a_pS318_S321 by ANTXRL expression — UCEC

Explore this box plot interactively →