ANTXR1

Across TCGA pan-cancer cohorts, ANTXR1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ANTXR1 data layer compared with 10 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ANTXR1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ANTXR1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

UVM, ACC, and HNSC are the cancer types where ANTXR1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.731	0.950	<.001	97	view →
ACC	DFS	Median	All	0.219	0.663	<.001	82	view →
HNSC	DFS	Median	IV	0.667	0.482	.001	49	view →
KIRC	DFS	Tertile	All	0.824	0.541	<.001	46	view →
STAD	OS	Quartile	II,III,IV	0.216	0.554	.002	43	view →
THCA	OS	Quartile	All	0.970	1.000	.003	42	view →
BLCA	OS	Tertile	All	0.458	0.735	.011	35	view →
CESC	DFS	Median	All	0.765	0.873	.002	26	view →
UCS	DFS	Tertile	IV	0.981	0.565	.024	22	view →
LAML	DFS	Quartile	All	0.487	0.269	.008	20	view →
LUAD	OS	Tertile	II,III,IV	0.613	0.329	.016	14	view →
UCEC	DFS	Quartile	II,III,IV	0.896	0.736	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ANTXR1–UVM (OS)

Open the UVM breakdown →