ANPEP

Across TCGA pan-cancer cohorts, ANPEP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ANPEP data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ANPEP mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ANPEP expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

HNSC, COAD, and LSCC are the cancer types where ANPEP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.915	0.775	.008	40	view →
COAD	DFS	Tertile	III,IV	1.000	0.758	.024	30	view →
LSCC	OS	Quartile	All	0.655	0.906	.009	17	view →
GBM	OS	Tertile	All	0.773	0.933	.008	10	view →
LUAD	DFS	Quartile	All	0.657	1.000	.035	1	view →
PDAC	DFS	Quartile	III,IV	0.564	0.889	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ANPEP–HNSC (OS)

Open the HNSC breakdown →