ANPEP

Across TCGA patient cohorts, ANPEP mutation is significantly associated with the RNA expression of many other genes, with 4,079 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANPEP-associated genes across cancer lineages are KCNIP2-AS1, RNA5SP412, and COX15. Each is linked with ANPEP in more than 3 cancer types. Because this analysis shows association rather than direction, both ANPEP-to-partner and partner-to-ANPEP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNIP2-AS1 grouped by ANPEP-low versus ANPEP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANPEP→partner) and Y-score (partner→ANPEP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KCNIP2-AS1 →	+0.260	+1.660	<.001	.003	3	4
UCEC	RNA5SP412 →	+0.398	+1.597	<.001	.001	3	3
COAD	COX15 →	+0.415	+3.200	.001	.009	3	3
SKCM	SKA1 →	+0.542	+2.247	<.001	.005	3	3
UCEC	DONSON →	+0.344	+1.901	.003	<.001	3	3
SKCM	TYW3 →	+0.456	+1.924	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,079 associations by consensus.

KCNIP2-AS1 by ANPEP expression — UCEC

Explore this box plot interactively →