ANPEP

Across TCGA patient cohorts, ANPEP mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANPEP-associated genes across cancer lineages are MEK1, Cyclin-B1, and Shc_pY317. Each is linked with ANPEP in more than 2 cancer types. Because this analysis shows association rather than direction, both ANPEP-to-partner and partner-to-ANPEP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ANPEP-low versus ANPEP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANPEP→partner) and Y-score (partner→ANPEP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MEK1 →	+0.350	+2.169	.008	.003	3	3
UCEC	Cyclin-B1 →	+0.510	+1.999	.002	.008	3	3
UCEC	Shc_pY317 →	-0.201	-1.999	<.001	<.001	3	2
SKCM	PCNA →	+0.145	+1.765	.044	.013	3	2
SKCM	Bid →	-0.130	-1.415	.040	.045	3	2
UCEC	A-Raf_pS299 →	-0.163	-3.169	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

MEK1 by ANPEP expression — SKCM

Explore this box plot interactively →