ANPEP

Across TCGA cell cohorts, ANPEP mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANPEP-associated genes across cancer lineages are TEDDM1, ASB17, and NLRP8. Each is linked with ANPEP in more than 1 cancer types. Because this analysis shows association rather than direction, both ANPEP-to-partner and partner-to-ANPEP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEDDM1 grouped by ANPEP-low versus ANPEP-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANPEP→partner) and Y-score (partner→ANPEP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TEDDM1 →	+0.031	+4.094	<.001	.001	3	2
OVARY	ASB17 →	+0.011	+3.807	<.001	.009	3	2
BLOOD_Lymphoma	NLRP8 →	+0.072	+4.867	<.001	.009	3	2
KIDNEY	KCNC2 →	+0.029	+4.491	<.001	.002	3	1
URINARY_TRACT	SPATA16 →	+0.020	+4.217	.004	.005	3	1
URINARY_TRACT	OPRPN →	+0.045	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

TEDDM1 by ANPEP expression — SKIN

Explore this box plot interactively →