ANP32C

Across TCGA pan-cancer cohorts, ANP32C RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ANP32C data layer compared with 1 for mutation status.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher ANP32C RNA is associated with better overall survival. In most high-consensus cancer types, elevated ANP32C expression acts as an unfavorable survival marker, although some lineages such as CESC and THCA show a favorable association.

CESC, MESO, and THCA are the cancer types where ANP32C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	II,III,IV	0.877	0.632	<.001	38	view →
MESO	OS	Tertile	III,IV	0.456	0.674	.003	37	view →
THCA	OS	Quartile	II,III,IV	1.000	0.720	.001	31	view →
KIRC	OS	Tertile	All	0.876	0.770	.005	21	view →
ACC	OS	Median	All	0.757	0.962	<.001	21	view →
KIRP	OS	Quartile	All	0.882	0.954	.013	17	view →
GBM	DFS	Tertile	All	0.402	0.156	.001	15	view →
DLBC	DFS	Median	All	1.000	0.513	<.001	14	view →
STAD	OS	Quartile	III,IV	0.275	0.605	.015	12	view →
LUSC	OS	Quartile	II,III,IV	0.601	0.300	.001	11	view →
BRCA	DFS	Tertile	All	0.435	0.592	.003	10	view →
SCLC	OS	Tertile	IV	0.205	0.587	.049	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ANP32C–CESC (OS)

Open the CESC breakdown →