ANP32B

Across TCGA pan-cancer cohorts, ANP32B mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ANP32B data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ANP32B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ANP32B expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where ANP32B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.933	0.446	.002	47	view →
HNSC	OS	Median	All	0.789	0.918	.002	18	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	9	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
LUAD	DFS	Median	III,IV	0.432	0.925	.047	3	view →
GBM	DFS	Tertile	All	0.665	0.885	.022	2	view →
CCRCC	OS	Median	II,III,IV	0.873	1.000	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ANP32B–LSCC (DFS)

Open the LSCC breakdown →