ANP32B

Across TCGA patient cohorts, ANP32B mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANP32B-associated genes across cancer lineages are eEF2, A-Raf_pS299, and FOXO3a_pS318_S321. Each is linked with ANP32B in more than 1 cancer types. Because this analysis shows association rather than direction, both ANP32B-to-partner and partner-to-ANP32B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ANP32B-low versus ANP32B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANP32B→partner) and Y-score (partner→ANP32B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.371	+2.321	.012	.033	3	1
UCEC	A-Raf_pS299 →	-0.140	-2.000	.004	.030	3	1
UCEC	FOXO3a_pS318_S321 →	-0.137	-2.575	.007	.010	3	1
UCEC	ACC_pS79 →	+0.300	+3.009	.036	.019	3	1
UCEC	ACC1 →	+0.358	+1.807	.017	.027	3	1
UCEC	GSK3-a-b →	+0.119	+2.321	.032	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

eEF2 by ANP32B expression — UCEC

Explore this box plot interactively →