ANP32A

Across TCGA pan-cancer cohorts, ANP32A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ANP32A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ANP32A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ANP32A is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, BLCA, and LIHC are the cancer types where ANP32A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANP32A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.929	<.001	12	view →
BLCA	All	All	+0.712	<.001	10	view →
LIHC	Female	II,III,IV	+1.085	<.001	9	view →
STAD	Male	II,III,IV	+1.003	<.001	6	view →
BRCA	All	III,IV	+0.437	<.001	6	view →
CHOL	All	All	+1.969	<.001	5	view →
LUSC	All	All	+0.418	<.001	4	view →
ESCA	All	II,III,IV	+1.075	.029	3	view →
COAD	Male	II,III,IV	+0.248	.031	3	view →
KICH	All	All	−0.383	.009	2	view →
KIRC	All	All	+0.158	.014	2	view →
LUAD	Male	II,III,IV	+0.344	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ANP32A–HNSC

Open the HNSC breakdown →