ANOS1

Across TCGA patient cohorts, ANOS1 mutation is significantly associated with the RNA expression of many other genes, with 3,640 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANOS1-associated genes across cancer lineages are H2AC14, BRK1, and MIR511. Each is linked with ANOS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANOS1-to-partner and partner-to-ANOS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2AC14 grouped by ANOS1-low versus ANOS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANOS1→partner) and Y-score (partner→ANOS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	H2AC14 →	+0.634	+1.539	<.001	.004	3	3
SKCM	BRK1 →	+0.394	+3.465	.006	.003	3	3
STAD	MIR511 →	+0.241	+2.042	.003	.009	3	3
STAD	SNRPD3 →	+0.352	+2.840	.003	.001	3	3
STAD	CDKN3 →	+0.693	+3.334	.004	.005	3	3
STAD	GAPDH →	+0.704	+3.509	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,640 associations by consensus.

H2AC14 by ANOS1 expression — UCEC

Explore this box plot interactively →