ANOS1

Across TCGA patient cohorts, ANOS1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANOS1-associated genes across cancer lineages are Caspase-7-cleavedD198, TIGAR, and ETS-1. Each is linked with ANOS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ANOS1-to-partner and partner-to-ANOS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ANOS1-low versus ANOS1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANOS1→partner) and Y-score (partner→ANOS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caspase-7-cleavedD198 →	+1.227	+3.321	<.001	.009	3	4
UCEC	TIGAR →	+0.114	+1.804	.019	.001	3	3
STAD	ETS-1 →	+0.255	+3.321	.032	.009	3	2
STAD	FASN →	+0.400	+2.459	.026	.019	3	2
STAD	PCNA →	+0.402	+3.169	.001	.018	3	2
STAD	4E-BP1 →	+0.518	+3.169	<.001	.018	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Caspase-7-cleavedD198 by ANOS1 expression — STAD

Explore this box plot interactively →