ANO8

Across TCGA pan-cancer cohorts, ANO8 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ANO8 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ANO8 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ANO8 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, LUAD, and GBM are the cancer types where ANO8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	1.000	0.582	.015	35	view →
LUAD	DFS	Median	II,III,IV	0.767	1.000	.014	8	view →
GBM	OS	Median	All	0.651	0.873	.008	7	view →
HNSC	OS	Median	All	0.595	1.000	.012	4	view →
LSCC	DFS	Median	III,IV	0.916	0.502	.035	1	view →
PDAC	DFS	Tertile	All	1.000	0.590	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ANO8–CCRCC (DFS)

Open the CCRCC breakdown →