ANO8

Across TCGA patient cohorts, ANO8 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANO8-associated genes across cancer lineages are ATM, Annexin-1, and Caspase-7-cleavedD198. Each is linked with ANO8 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANO8-to-partner and partner-to-ANO8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ANO8-low versus ANO8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANO8→partner) and Y-score (partner→ANO8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.511	-1.847	.002	.008	3	3
UCEC	Annexin-1 →	+0.749	+3.807	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.549	+2.135	.011	.010	3	2
BLCA	p53 →	+0.312	+2.820	.022	.035	2	2
UCEC	ERK2 →	+0.189	+1.847	.007	.008	3	1
UCEC	Lck →	+0.174	+1.502	.018	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ATM by ANO8 expression — UCEC

Explore this box plot interactively →