ANO5

Across TCGA patient cohorts, ANO5 mutation is significantly associated with the total protein of many other genes, with 95 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANO5-associated genes across cancer lineages are 4E-BP1, ASNS, and eEF2. Each is linked with ANO5 in more than 4 cancer types. Because this analysis shows association rather than direction, both ANO5-to-partner and partner-to-ANO5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ANO5-low versus ANO5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANO5→partner) and Y-score (partner→ANO5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	4E-BP1 →	+0.312	+3.169	.008	.017	3	5
UCEC	ASNS →	+0.274	+1.125	.003	.029	3	5
UCEC	eEF2 →	+0.228	+1.584	.014	.015	3	4
COAD	Cyclin-B1 →	+0.626	+1.815	.001	.016	1	5
COAD	JNK_pT183_Y185 →	-0.198	-1.798	.040	.026	3	3
COAD	Notch1 →	+0.155	+3.000	.024	.034	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 95 associations by consensus.

4E-BP1 by ANO5 expression — SKCM

Explore this box plot interactively →