ANO5

Across TCGA cell cohorts, ANO5 mutation is significantly associated with the RNA expression of many other genes, with 143 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANO5-associated genes across cancer lineages are CCL24, IL36A, and OR7G3. Each is linked with ANO5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANO5-to-partner and partner-to-ANO5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL24 grouped by ANO5-low versus ANO5-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANO5→partner) and Y-score (partner→ANO5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CCL24 →	+0.153	+4.269	<.001	.005	3	1
LUNG_SCLC	IL36A →	+0.020	+4.643	<.001	.004	3	1
LUNG_SCLC	OR7G3 →	+0.047	+4.643	<.001	.004	3	1
LUNG_SCLC	FAM25A →	+0.140	+4.643	<.001	.004	3	1
LUNG_SCLC	SLC15A5 →	+0.046	+4.269	<.001	.005	3	1
LUNG_SCLC	DUXA →	+0.039	+4.523	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 143 associations by consensus.

CCL24 by ANO5 expression — LUNG_SCLC

Explore this box plot interactively →