ANO4

Across TCGA pan-cancer cohorts, ANO4 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated ANO4 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ANO4 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated ANO4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, PRAD, and LIHC are the cancer types where ANO4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	1.000	0.805	.010	28	view →
PRAD	DFS	Median	All	0.356	0.890	<.001	12	view →
LIHC	DFS	Median	All	0.143	0.541	<.001	9	view →
LUAD	DFS	Median	All	1.000	0.659	.016	9	view →
READ	OS	Median	III,IV	0.644	0.932	<.001	8	view →
BLCA	DFS	Median	All	0.662	0.328	.037	6	view →
ESCA	OS	Median	All	0.353	0.706	.019	6	view →
HNSC	OS	Median	All	0.545	0.771	.044	2	view →
LUSC	DFS	Median	All	1.000	0.453	.018	2	view →
SKCM	DFS	Median	IV	1.000	0.201	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

ANO4–UCEC (OS)

Open the UCEC breakdown →