ANO3

Across TCGA patient cohorts, ANO3 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANO3-associated genes across cancer lineages are Caspase-7-cleavedD198, ASNS, and CDK1. Each is linked with ANO3 in more than 4 cancer types. Because this analysis shows association rather than direction, both ANO3-to-partner and partner-to-ANO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ANO3-low versus ANO3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANO3→partner) and Y-score (partner→ANO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.571	+1.765	.001	.011	3	5
COAD	ASNS →	+0.516	+2.178	.005	.035	3	3
LUAD	CDK1 →	+0.170	+2.321	<.001	.006	3	3
UCEC	4E-BP1 →	+0.246	+3.807	.002	<.001	3	3
UCEC	TFRC →	+0.355	+2.000	.027	.029	3	3
STAD	c-Kit →	-0.445	-3.169	.004	.019	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

Caspase-7-cleavedD198 by ANO3 expression — UCEC

Explore this box plot interactively →