ANO1

Across TCGA pan-cancer cohorts, ANO1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ANO1 data layer compared with 17 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ANO1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ANO1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

LSCC, GBM, and UCEC are the cancer types where ANO1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.541	0.902	.001	17	view →
GBM	DFS	Quartile	All	0.485	0.841	.017	9	view →
UCEC	DFS	Median	All	0.915	0.774	.025	6	view →
LUAD	OS	Median	III,IV	0.796	0.410	.035	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ANO1–LSCC (DFS)

Open the LSCC breakdown →