ANO1

Across TCGA patient cohorts, ANO1 mutation is significantly associated with the RNA expression of many other genes, with 3,576 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANO1-associated genes across cancer lineages are MIR1268A, BNIP3P2, and ESS2. Each is linked with ANO1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANO1-to-partner and partner-to-ANO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1268A grouped by ANO1-low versus ANO1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANO1→partner) and Y-score (partner→ANO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR1268A →	+0.234	+1.900	<.001	.005	3	3
OV	BNIP3P2 →	+0.101	+5.384	<.001	.005	3	3
UCEC	ESS2 →	+0.213	+1.595	.003	<.001	3	3
UCEC	TFIP11 →	+0.414	+2.042	.001	<.001	3	3
SKCM	SNU13 →	+0.297	+3.846	.006	<.001	3	3
SKCM	MCAT →	+0.439	+2.328	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,576 associations by consensus.

MIR1268A by ANO1 expression — SKCM

Explore this box plot interactively →