ANO1

Across TCGA patient cohorts, ANO1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANO1-associated genes across cancer lineages are 4E-BP1, eIF4E, and p70-S6K_pT389. Each is linked with ANO1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ANO1-to-partner and partner-to-ANO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ANO1-low versus ANO1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANO1→partner) and Y-score (partner→ANO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	4E-BP1 →	+0.251	+3.000	.015	.035	3	4
UCEC	eIF4E →	+0.237	+3.013	<.001	<.001	3	3
UCEC	p70-S6K_pT389 →	-0.188	-2.415	.001	.002	3	3
UCEC	ATM →	-0.499	-3.074	<.001	<.001	3	3
SKCM	SETD2 →	-0.146	-2.222	.015	.010	3	2
SKCM	53BP1 →	+0.315	+1.700	.046	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

4E-BP1 by ANO1 expression — COAD

Explore this box plot interactively →