ANO1

Across TCGA cell cohorts, ANO1 mutation is significantly associated with the RNA expression of many other genes, with 228 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANO1-associated genes across cancer lineages are CFAP97D2, BMP10, and TRRAP. Each is linked with ANO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANO1-to-partner and partner-to-ANO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFAP97D2 grouped by ANO1-low versus ANO1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANO1→partner) and Y-score (partner→ANO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CFAP97D2 →	+0.043	+5.087	<.001	.004	3	2
LARGE_INTESTINE	BMP10 →	+0.013	+2.397	.002	.003	3	2
LARGE_INTESTINE	TRRAP →	+0.593	+3.169	.003	.009	3	2
BREAST	GABRA6 →	+0.110	+2.736	.001	.002	3	2
BLOOD_Leukemia	OR2A5 →	+0.021	+4.922	<.001	.009	3	2
BLOOD_Myeloma	MOS →	+0.040	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 228 associations by consensus.

CFAP97D2 by ANO1 expression — URINARY_TRACT

Explore this box plot interactively →