ANLN

Across TCGA patient cohorts, ANLN mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANLN-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and eEF2. Each is linked with ANLN in more than 2 cancer types. Because this analysis shows association rather than direction, both ANLN-to-partner and partner-to-ANLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ANLN-low versus ANLN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANLN→partner) and Y-score (partner→ANLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.410	+1.847	<.001	.007	3	3
UCEC	Caspase-7-cleavedD198 →	+0.504	+2.267	.006	<.001	3	3
UCEC	eEF2 →	+0.333	+1.999	.002	.008	3	2
UCEC	eIF4E →	+0.214	+2.169	.001	<.001	3	2
UCEC	FoxM1 →	+0.186	+1.893	.020	<.001	3	2
UCEC	FOXO3a_pS318_S321 →	-0.092	-1.382	.017	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

ASNS by ANLN expression — UCEC

Explore this box plot interactively →